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    Ask anyone suffering from gastroesophageal reflux disease (GERD), and he or she will tell you how medications like Zantac helps to make it more bearable.

    However, it begs the question: is Zantac safe to take over a long period of time? Keep reading below to find out.

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    What Are Acid Reducers and how do They Work?

    Proton Pump Inhibitors (PPIs) and H2 Blockers are medications that are both approved for treating chronic heartburn or GERD. Both of these medications help to suppress gastric acid secretion in the stomach1.

    However, there are key differences between the two.

    According to Very Well, PPIs shut down the proton pumps in the stomach, while H2 Blockers block the histamine receptors in acid-producing cells in the stomach.

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